Pentanamide,N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-,(2S)-

Name	Pentanamide,N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-,(2S)-
Synonyms	MK-0822 Odanacatib ODANACATIB Odanacatib,MK-0822,MK0822 (S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide (2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]pentanamide Pentanamide,N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-,(2S)- Pentanamide, N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-, (2S)- Odanacatib (2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]pentanamide (2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]pentanamide Odanacatib (MK-0822)
CAS	603139-19-1
EINECS	682-460-8

Molecular Formula	C25H27F4N3O3S
Molar Mass	525.56
Density	1.35
Melting Point	223-224 °C
Boling Point	681.6±55.0 °C(Predicted)
Solubility	Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Sonicated)
Appearance	Solid
Color	White to Off-White
pKa	12.06±0.20(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Use	A cathepsin K inhibitor.
In vitro study	In Vitro, Odanacatib has high inhibitory activity and selectivity on cathepsin K. When it acts on human and rabbit cathepsin K, The IC50 is 0.2 nM and 1 nM respectively. Moreover, Odanacatib was equally effective in all human cell enzyme assays, with an IC50 of 5 nM. Recent studies have shown that Odanacatib causes a decrease in Osteoclast(OC) resorption activity by blocking intracellular vesicle transport.
In vivo study	Odanacatib at a dose of 10 mg/kg in preclinical rats has good pharmacokinetic properties, such as clearance (Cl: 2 mL kg Odanacatib(ODN) oral treatment ovariectomized (OVX) the rabbits also blocked bone loss, and this effect was dose-dependent. Moreover, treatment with Odanacatib at 9 µm daily significantly increased bone mineral density in the proximal femur (BMD) (7.8%), femoral neck (10.8%), and greater trochanter BMD(6.5%). Odanacatib effectively inhibits bone metabolism in long-term estrogen-deficient, skeletal mature rhesus monkeys, does not reduce the number of osteoclasts, and maintains the normal biomechanical properties of the spine in ovariectomized (OVX) non-human primates.

Last Update：2024-01-02 23:10:35

biological activity	Odanacatib (MK-0822) is a potent, selective, cathepsin K (human/Rabbit) the neutral inhibitor, with an IC50 of 0.2 nM/1 nM, is highly selective for the off-target cathepsin B, L, S. Phase 3. Odanacatib (MK-0822) is a potent, selective, neutral inhibitor of cathepsin K (human/Rabbit) with an IC50 of 0.2 nM/1 nM for the off-target cathepsin B, L, S has a high degree of selectivity. Phase 3.
characteristics	Odanacatib is a potent selective neutral inhibitor of cathepsin K.
Target	Value
Cathepsin K (human) ()	0.2 nM
Cathepsin K (rabbit) ()	1 nM

Last Update：2024-04-09 19:05:13

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Pentanamide,N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-,(2S)- Request for Quotation